Journal article
Functional analysis of genes in regions commonly amplified in high-grade serous and endometrioid ovarian cancer
SJ Davis, KE Sheppard, RB Pearson, IG Campbell, KL Gorringe, KJ Simpson
Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2013
Abstract
Purpose: Ovarian cancer has the highest mortality rate of all the gynecologic malignancies and is responsible for approximately 140,000 deaths annually worldwide. Copy number amplification is frequently associated with the activation of oncogenic drivers in this tumor type, but their cytogenetic complexity and heterogeneity has made it difficult to determine which gene(s) within an amplicon represent(s) the genuine oncogenic driver. We sought to identify amplicon targets by conducting a comprehensive functional analysis of genes located in the regions of amplification in high-grade serous and endometrioid ovarian tumors. Experimental Design: High-throughput siRNA screening technology was use..
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Grants
Awarded by Australian National Health and Medical Research Council
Funding Acknowledgements
This study was funded by an Australian National Health and Medical Research Council project grant (#566603) and the Emer Casey Foundation. S.J. Davis is supported by a Cancer Council of Victoria Postgraduate Scholarship. The Victorian Centre for Functional Genomics (VCFG) is funded by the Australian Cancer Research Foundation (ACRF), the Victorian Department of Industry, Innovation and Regional Development (DIIRD), the Australian Phenomics Network supported by funding from the Australian Government's Education Investment Fund through the Super Science Initiative, the Australasian Genomics Technologies Association (AMATA), and the Brockhoff Foundation.